Route is a tool for viewing and manipulating the kernel's IP routing table
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With route(8) you can configure your network routing to other hosts and gateways. You may have a bunch of virtual machines with a certain routing scheme, or physical computers with many NICs (Network Interface Card, or just network adapter). If you have a OpenBSD shell access you can try to show the current routing parameters of the machine.
Examples
$ route -n show # Show routing table without resolving DNS names
$ route show # Show routing table and solve DNS names
To add a route to the network 192.168.5.0/24 use:
$ route add -inet 192.168.5.0/24 192.168.0.1
where the latter address is the gateway\
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To change the default gateway:\
edit the file /etc/mygate directly\
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Please consider the route manual page for more information.